Mathematical modeling of pathogenicity of Cryptococcus neoformans

DETECTION OF CRYPTOCOCCUS NEOFORMANS BY SEMINESTED PCR IN CEREBROSPINAL FLUID

 ABSTRACT Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years. Cryptococcus neoformans is recognized as the most frequent fungal infection of the central nervous system (CNS) in immunocompetent as well as immunocompromised patients. We report the development of a semi-nested- PCR-based assay for the ...

TO : Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans

Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.

The pathogenic fungus Cryptococcus neoformans infects humans upon inhalation and causes the most common fungal meningoencephalitis in immunocompromised subjects worldwide. In the host, C. neoformans is found both intracellularly and extracellularly, but how these two components contribute to the development of the disease is largely unknown. Here we show that the glycosphingolipid glucosylceram...

Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans

Cryptococcus neoformans is an opportunistic human pathogenic fungus that causes meningoencephalitis. Due to the increasing global risk of cryptococcosis and the emergence of drug-resistant strains, the development of predictive genetics platforms for the rapid identification of novel genes governing pathogenicity and drug resistance of C. neoformans is imperative. The analysis of functional gen...

Lack of Cryptococcus gattii from Eucalyptus in Ahvaz

The basidiomycetous yeast genus Cryptococcus contains two medically important pathogens, Cryptococcus neoformans and C. gattii [1-3]. C. neoformans is one of the common pathogens in acquired immunodeficiency syndrome (AIDS), whereas the most cases of diseases due to C. gattii happened in the healthy individuals [2, 4]. C. gattii has a tendency to affect the respiratory and nervous systems of th...